Cardiovascular and Metabolic Diseases Comorbid with Psoriasis: Beyond the Skin
نویسندگان
چکیده
A close association of systemic inflammation with cardiovascular diseases and metabolic syndrome is recently a popular topic in medicine. Psoriasis is a chronic inflammatory skin disease with a prevalence of approximately 0.1-0.5% in Asians. It is characterized by widespread scaly erythematous macules that cause significant physical and psychological burdens for the affected individuals. The accelerated inflammation driven by the TNF-α/IL-23/IL-17A axis is now known to be the major mechanism in the development of psoriasis. Psoriasis is not a mere skin disease; it is significantly associated with cardiovascular diseases and metabolic syndrome, which suggests that the chronic skin inflammation extends the systemic inflammation beyond the skin. In this article, we review the epidemiological and pathological aspects of psoriasis and its comorbidities.
منابع مشابه
Assessment of P-wave indices as atrial fibrillation predictors in psoriasis patients
Background: Psoriasis is a prevalent chronic T cell mediated inflammatory skin disorder. Recent studies have reported an increase in the incidence of arrhythmia in psoriasis patients who run an excessive risk of metabolic syndrome and cardiovascular diseases. P-wave dispersion (PWD) and duration are important electrocardiographic (ECG) markers employed to anticipate the risk of atrial arrhythmi...
متن کاملPsoriasis and comorbidities: links and risks
Psoriasis is a chronic inflammatory skin disease affecting approximately 2% of the population worldwide. In the past decade, many studies have drawn attention to comorbid conditions in psoriasis. This literature review examines the epidemiological evidence, pathophysiological commonalities, and therapeutic implications for different comorbidities of psoriasis. Cardiovascular disease, obesity, d...
متن کاملNon-alcoholic hepatic steatosis Comorbidities Related to Impaired Quality of Life Anxiety, Depression, Smoking, Alcoholism Comorbidities Related to Treatment Nephrotoxicity, hepatotoxicity, dyslipidemia, skin cancer
The consistency of association and the diversity of comorbidities reported in psoriasis warrants it to be labelled as a complex syndrome. Merely finding an association between psoriasis and comorbidities is not going to suffice until this evidence is put into clinical practice. The pathogenesis of psoriasis and its comorbidities is complex but several studies have revealed certain mechanisms an...
متن کاملPsoriasis as the marker of underlying systemic disease.
Psoriasis is associated with comorbidities that include metabolic syndrome and increased cardiovascular risk. These conditions share etiologic features and health consequences that directly correlate with the severity of psoriatic disease. This disease, in both its skin and joint manifestations, may represent a relevant healthcare issue as an indicator of a broader, underlying disorder of syste...
متن کاملRace and Ethnic Differences in the Associations between Cardiovascular Diseases, Anxiety, and Depression in the United States
Introduction: Although cardiovascular diseases and psychiatric disorders are linked, it is not yet known if such links are independent of comorbid medical diseases and if these associations depend on race and ethnicity. This study aimed to determine if the associations between cardiovascular diseases with general anxiety disorder (GAD) and major depressive episode (MDE) are ind...
متن کامل